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Chemistry
Research

Research


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Contact Chemistry
Ghosh Science & Technology Center
Suite ST-410
508-929-8583

Chemistry Research Opportunities at Worcester State

Collaborating with your professors on research projects will reinforce classroom learning and expose you to best research practices. Here, you will have the opportunity to join in faculty-led undergraduate research on topics like organic chemistry, bioanalytical chemistry, and inorganic and molecular modeling.

We also promote interdisciplinary research with other Worcester State departments in physics, biology, and the natural sciences.

Chemistry Research Presentations
Imines: Microwave Synthesis for the Creation of Novel Antibiotics
Imines were synthesized in high yield from amines and aldehydes using microwave irradiation with water as the solvent. The imines have been coordinated to metals, forming mono-, bi-, and tri-dentate complexes. Imines have known antibacterial and antifungal properties and coordination of imines to metals is known to enhance these properties. These complexes have been evaluated against various bacteria to determine their antibacterial activity.
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Partridgeberry: VOC Emissions and Metals Within the Soil
Mitchella repens (partridgeberry) was investigated interdisciplinarily. The chemistry team characterized the volatile organic compounds (VOCs) at different stages of the flowering process using Solid Phase Micro Extraction (SPME) devices in unison with a GC/MS. Alpha-pinene was the most concentrated of the identified VOCs; its concentration decreased as the flowering process continued. The soil was analyzed via ICP-OES to compare 16 metals’ concentrations.
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Reaction of HNO with GAPDH: Development of GAPDH Assay for Undergraduate Biochemistry Lab
Nitroxyl (HNO) has been shown to have unique pharmacological chemistry as well as therapeutic advantages in comparison to other nitrogen oxide species. Research was conducted to determine the drug’s effect on glyceraldehyde-3-phosphate dehydrogenase (GAPDH) activity in conditions of pH 7 and 10, with the goal of developing an assay that can be implemented into a biochemistry lab curriculum. Both direct oxidation and reversibility of this effect on GAPDH were examined.
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COVID-19 and Chemistry
Chemistry has been crucial to understanding and fighting COVID-19. For example, chemists have helped define the structure of the virus and develop different diagnostic tests for COVID-19. The connection between chemistry and COVID-19 was researched and presented as an informative bulletin board for students and staff at Worcester State University. The bulletin board provided clarity to frequently asked questions and concerns the public/students may have.
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How Green Is Your Nail Polish Remover?
In this study, a standard addition method using Nuclear Magnetic Resonance (NMR) was used to calculate the concentration of dimethyl adipate and dimethyl succinate in a nail polish remover marketed as acetone-free and non-toxic. The results were used to determine if the product was truly green as marketed.
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Method Validation for Characterizing Volatile Organic Compounds from Flowers of Mitchella repens
An analytical method using SPME and GCMS was developed to characterize volatile organic compounds produced by flowers of the native plant Mitchella repens. COVID-19 restricted research during the plant’s already brief flowering period, leaving no opportunity to determine the accuracy and precision of the method in the initial phase of research. The aim of the project was to determine sources of errant peaks and validate the method using a pure terpene standard.
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Portrait of Nhu Le, Chemistry
As a Chemistry major, I've worked on multiple research projects, including developing ultra-small and biocompatible nanomaterials for biomedical applications at the Children's Medical Center at UMass.
— Nhu Le, Biochemistry
Portait of Ryan Lindsay, '18
Research at Worcester State is encouraged and available to anyone who wants to further their education. I conducted research in green chemistry with a faculty member, and we were able to present our findings at several conferences!
— Ryan Lindsay '18

Recent Chemistry Research at Worcester State

Stabilization of Chelating Complexes Using Computational Analysis

Bidentate chelating ligands of a metal ion result in a more stable molecule due to the chelate effect in comparison to monodentate ligands. The enthalpic contribution to the stabilization of metal ion complexes was examined as ligands change from monodentate to bidentate.
Faculty Advisor: Eihab Jaber, Ph.D.

Phosphate Analysis of Water Bodies in Central Massachusetts

In this experiment, phosphate levels were measured in several water bodies throughout Central Massachusetts, including Lake Ellie and Patch Reservoir. Elevated levels of phosphate may appear in surface water, causing plants to grow excessively
Faculty Advisors: Kathleen C. Murphy, Ph.D., Timothy L. Cook, Ph.D., Daron Barnard, Ph.D.

Dissociative Spillover Mechanism of Molecular Hydrogen on Nickel-Decorated Graphene

Hydrogen is a promising alternative to hydrocarbon fuels, and a possible method for the storage of the element may be on carbon nanotubes. A mechanism known as spillover is hypothesized to increase hydrogen storage on these metal-decorated nanotubes.
Faculty Advisor: Joseph Quattrucci, Ph.D.

Phosphate in Detergents: A Greener Spectroscopic Method

An antimony-free spectrophotometric method to determine phosphate concentration was investigated for use in an undergraduate lab. The new technique proposed utilizes fewer hazardous chemicals than the standard method (EPA Method 365.3) and is conscientious of waste prevention, with reduced sample volumes and reduced molar concentrations of reactants.
Faculty Advisor: Meghna Dilip, Ph.D.

The Removal of Phosphates from an Aqueous Solution Using a Bicomposite Metal

Adsorption is a method of water decontamination to remove oxyanions that pose a threat to the environment. This experimental study resulted in the synthesis of an inorganic biocomposite adsorbent. Its ability to remove phosphate from an aqueous solution was exhibited via UV-VIS spectroscopy.
Faculty Advisors: Jeremy R. Andreatta, Ph.D., Joseph Quattrucci, Ph.D.

C-H Activation and Functionalization of Arenes Using Ir Catalysts

Previous work has demonstrated that C-H bond activation and functionalization is attainable for a Cp*Ir catalyst. C-H functionalization involves the cleavage of an aryl or benzyl C-H bond mediated by a carbonate base and replacing it with a C-X bond.
Faculty Advisors: Jeremy R. Andreatta, Ph.D., Margaret E. Kerr, Ph.D.

Hybrid Quantum/Molecular Mechanic Study on the Reaction Mechanism of Nitroxyl and Thiol Derivatives

Nitroxyl (HNO) is a nitrogen compound that has been shown to strongly react with thiols, while reactions with selenothiols have exhibited lower energetic barriers than that of sulfur analogues.
Faculty Advisor: Joseph Quattrucci, Ph.D.

Analysis of the Stabilization Energy Contributions of Individual Hydrogen Bonding

We present a novel computational methodology that has facilitated the characterization of each individual hydrogen bond’s energy contribution to the complex’s stability while selectively breaking individual bonds.
Faculty Advisors: Eihab Jaber, Ph.D., Jeffry C. Nichols, Ph.D.

Iridium Complex as Catalyst for C-C Bond Formation

Previous work has demonstrated that C-H bond activation and functionalization is attainable for a Cp*Ir catalyst. C-H functionalization involves the cleavage of an aryl or benzyl C-H bond mediated by a carbonate base, and replaces it with a C-X bond.
Faculty Advisors: Jeremy R. Andreatta, Ph.D., Margaret E. Kerr, Ph.D.

Students Create Videos to Explain Chemistry Experiments for Remote Learners

As the fall semester began, Weichu Xu, Ph.D., assistant professor of chemistry, realized the pandemic meant visits to the lab would be restricted for many students and impossible for those in isolation, so they would need extra help to prepare for and understand experiments. He thought videos on lab topics might fill the gap.

Read Story

DCU Investment Allows Summer Chemistry Workshop to Excel

Worcester State University’s Chemistry Department has been enriching the summers of local high school students by running an Environmental STEM (Science, Technology, Engineering, and Math) Connections program.

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Lamelas and Swaminathan Participate in Regional Chemistry Teachers Meeting

Francisco Lamelas, Ph.D., and Sudha Swaminathan, Ph.D., both of the Earth, Environment, and Physics Department, participated in the August 10, 2015, meeting of the New England Association of Chemistry Teachers at Clark University.

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